 | Clint Eastwood | | Monco |
| Lee Van Cleef | | Col. Douglas Mortimer |
| Gian Maria Volontè | | El Indio (The Indian) |
| Mara Krupp | | Mary - Hotel Manager's Beautiful Wife |
| Luigi Pistilli | | Groggy, Member of Indio's Gang |
| Klaus Kinski | | Juan Wild - The Hunchback |
| Luis Rodríguez | | Manuel, Member of Indio's Gang |
| Luis Rodríguez | | Manuel (Member of Indio's Gang) |
| Benito Stefanelli | | Luke 'Hughie' |
| Panos Papadopulos | | Sancho Perez, Member of Indio's Gang |
| Aldo Sambrell | | Cuchillio |
| Roberto Camardiel | | Tucumcari station clerk |
| Joseph Egger | | Old Prophet |
| Tomás Blanco | | Tucumcari sheriff |
| Lorenzo Robledo | | Tomaso, Indio's Traitor |
| Dante Maggio | | Carpenter in cell with El Indio |
| Sergio Mendizábal | | Tucumcari bank manager |
| Diana Rabito | | Callaway's beautiful girl in tub |
| Giovanni Tarallo | | Santa Cruz telegraphist |
| Mario Meniconi | | Train Conductor |
| Mario Brega | | Nino, Member of Indio's Gang |
