| Tim Curry | | Long John Silver |
| Billy Connolly | | Billy Bones |
| Jennifer Saunders | | Mrs. Bluveridge |
| Kevin Bishop | | Jim Hawkins |
| Dave Goelz | | The Great Gonzo / Dr. Bunsen Honeydew / Waldorf / Mudwell the Mudbunny / Zoot (voice) |
| Steve Whitmire | | Kermit the Frog / Rizzo the Rat / Beaker (voice) |
| Jerry Nelson | | Statler / Blind Pew / Mad Monty / Floyd Pepper / Lew Zealand / Tomato / Pirate / Skulls / Trelawney's Butler / Screaming Cat (voice) |
| Kevin Clash | | Bad Polly / Black Dog / Spa'am / Chicken / Miss Piggy (assistant) / Fozzie Bear (assistant) / Sam the Eagle (assistant) / Animal (assistant) / Walleyed Pike / Monkey / Pirate / Real Old Tom (voice) |
| Bill Barretta | | Clueless Morgan / Swedish Chef / Blind Pew (hands) / Pirate / Pig / Skulls (voice) |
| Frank Oz | | Miss Piggy / Fozzie Bear / Sam the Eagle / Animal (voice) |
| John Henson | | Sweetums (voice) |
| Danny Blackner | | Short Stack Stevens |
| Peter Geeves | | Black Eyed Pea |
| Harry Jones | | Easy Pete |
| David J. Nicholls | | Captain Flint |
| Frederick Warder | | Calico Jerry |
| Nigel Plaskitt | | Additional Muppet Performer |
| Louise Gold | | Female Tourist Rat / Rat Tour Guide (voice) |
| John Eccleston | | Additional Muppet Performer |
| Simon Buckley | | Additional Muppet Performer |
| Katherine Smee | | Additional Muppet Performer |
| Andrew Spooner | | Additional Muppet Performer |
| Robbie Barnett | | Additional Muppet Performer |
| James Barton | | Additional Muppet Performer |
| Michael Bayliss | | Additional Muppet Performer |
| Charles Broughton | | Additional Muppet Performer |
| David Bulbeck | | Additional Muppet Performer |
| Dave Chapman | | Additional Muppet Performer |
| Marcus Clarke | | Additional Muppet Performer |
| Sue Dacre | | Additional Muppet Performer |
| Taylor David | | Additional Muppet Performer |
| Geoff Felix | | Additional Muppet Performer |
| Mike Gallant | | Additional Muppet Performer |
| Pat Garrett | | Additional Muppet Performer |
| Barnaby Harrison | | Additional Muppet Performer |
| Mark Jefferis | | Additional Muppet Performer |
| William Todd-Jones | | Additional Muppet Performer |
| Robin Kingsland | | Additional Muppet Performer |
| Steven Kynman | | Additional Muppet Performer |
| Christopher Leith | | Additional Muppet Performer |