| Brendan Fraser | | DJ Drake / Brendan Fraser / Voice of Tasmanian Devil and She-Devil |
| Jenna Elfman | | Kate |
| Steve Martin | | Mr. Chairman |
| Timothy Dalton | | Damien Drake |
| Heather Locklear | | Dusty Tails |
| Joan Cusack | | Mother |
| Bill Goldberg | | Mr. Smith |
| Don Stanton | | Mr. Warner |
| Dan Stanton | | Mr. Warner's Brother |
| Dick Miller | | Security Guard |
| Roger Corman | | Hollywood Director |
| Kevin McCarthy | | Dr. Bennell |
| Jeff Gordon | | Jeff Gordon |
| Matthew Lillard | | Matthew Lillard |
| Mary Woronov | | Acme VP, Bad Ideas |
| Marc Lawrence | | Acme VP, Stating the Obvious |
| Bill McKinney | | Acme VP, Nitpicking |
| George Murdock | | Acme VP, Unfairly Promoted |
| Robert Picardo | | Acme VP, Rhetorical Questions |
| Ron Perlman | | Acme VP, Never Learning |
| Vernon Wells | | Acme VP, Child Labor (as Vernon G. Wells) |
| Leo Rossi | | Acme VP, Climbing to the Top |
| Archie Hahn | | Stunt Director |
| Allan Graf | | Interrogator |
| Austyn Cuccia | | Tour Bus Girl |
| Marie-Claude Jacques | | Flower Vendor |
| Michael Azria | | Paris Cafê Waiter |
| Dan Romanelli | | Studio Executive |
| Ryan O'Dell | | Bugs Bunny's Driver |
| Kevin Thompson | | Dancing Yosemite Sam |
| Arturo Gil | | Dancing Yosemite Sam |
| Gabriel Pimentel | | Dancing Yosemite Sam |
| Steve Babiar | | Dancing Yosemite Sam |
| Martin Klebba | | Dancing Yosemite Sam |
| Joe Alaskey | | Bugs Bunny / Daffy Duck / Beaky Buzzard / Sylvester / Mama Bear (voice) |
| Jeff Bennett | | Yosemite Sam / Foghorn Leghorn / Nasty Canasta (voice) (as Jeff Glenn Bennett) |
| Billy West | | Elmer Fudd / Peter Lorre (voice) |
| Eric Goldberg | | Tweety Bird / Marvin the Martian / Speedy Gonzalez (voice) |
| Bruce Lanoil | | Pepe Le Pew (voice) |
| June Foray | | Granny (voice) |