| Patrick Stewart | | Professor Charles Xavier |
| Hugh Jackman | | Logan / Wolverine |
| Ian McKellen | | Eric Lehnsherr / Magneto |
| Halle Berry | | Ororo Munroe / Storm |
| Famke Janssen | | Jean Grey |
| James Marsden | | Scott Summers / Cyclops |
| Anna Paquin | | Rogue |
| Rebecca Romijn | | Raven Darkholme / Mystique / Grace |
| Brian Cox | | William Stryker |
| Alan Cumming | | Kurt Wagner / Nightcrawler |
| Bruce Davison | | Senator Kelly |
| Aaron Stanford | | John Allerdyce / Pyro |
| Shawn Ashmore | | Bobby Drake / Ice Man |
| Kelly Hu | | Yuriko Oyama / Lady Deathstrike |
| Katie Stuart | | Shadowcat |
| Kea Wong | | Jubilation Lee / Jubilee |
| Cotter Smith | | President McKenna |
| Chiara Zanni | | White House Tour Guide |
| Jackie A. Greenbank | | President's Secretary |
| Michael Soltis | | White House Checkpoint Agent |
| Michael David Simms | | White House Agent (Lead Agent) |
| David Fabrizio | | Oval Office Agent Fabrizio |
| Roger Cross | | Oval Office Agent Cartwright |
| Richard Bradshaw | | Special Ops Agent |
| Bryce Hodgson | | Artie |
| Glen Curtis | | Museum Teenager #1 |
| Greg Rikaart | | Museum Teenager #2 |
| Shauna Kain | | Theresa Rourke / Siryn |
| Ty Olsson | | Mitchell Laurio |
| Alfonso Quijada | | Federal Bldg. Cleaning Twin #1 |
| Rene Quijada | | Federal Bldg. Cleaning Twin #2 |
| Brad Loree | | Stryker at age 40 |
| Sheri G. Feldman | | Augmentation Room Doctor |
| Connor Widdows | | Jones |
| Daniel Cudmore | | Piotr Rasputin / Colossus |
| Peter Wingfield | | Stryker Soldier Lyman |
| Charles Siegel | | Dr. Shaw |
| Steve Bacic | | Dr. Hank McCoy |
| Michael Reid MacKay | | Jason 143 |
| James Kirk | | Ronny Drake |