 | Antonio Banderas | | Puss in Boots (voice) |
| Salma Hayek | | Kitty Softpaws (voice) |
| Florence Pugh | | Goldilocks (voice) |
| Olivia Colman | | Mama Bear (voice) |
| Samson Kayo | | Baby Bear (voice) |
| Wagner Moura | | Wolf (voice) |
| Ray Winstone | | Papa Bear (voice) |
| Harvey Guillén | | Perrito (voice) |
| Da'Vine Joy Randolph | | Mama Luna (voice) |
| John Mulaney | | Jack Horner (voice) |
| Chris Miller | | (voice) |
| Anthony Mendez | | Doctor (voice) |
| Kevin McCann | | Ethical Bug (voice) |
| Miguel Gabriel | | Little Boy (voice) |
| Bernardo De Paula | | Governor / Little Boy's Father / Male Partier (voice) |
| Kaley Alyssa Flanagan | | (voice) |
| Betsy Sodaro | | Jo Serpent / Baker's Dozen Gang Member (voice) |
| Artemis Pebdani | | Jan Serpent (voice) |
| Conrad Vernon | | Gingy (voice) |
| Cody Cameron | | Pinocchio (voice) |
| Kailey Crawford | | Little Goldi (voice) |
| Al Rodrigo | | Bartender (voice) |
| Bob Persichetti | | Ohhh Cat (voice) |
| Pilar Uribe | | Governor's Assistant / Female Partier (voice) |
| Heidi Gardner | | Last Baker (voice) |
| Joel Crawford | | Band Member / Baker's Dozen Gang Member (voice) |
| Januel Mercado | | Band Member / Baker's Dozen Gang Member (voice) |
| James Ryan | | Little Jack Audience Member / Baker's Dozen Gang Member (voice) |
| Natalia Cronembold | | Waitress / Baker's Dozen Gang Member (voice) |
| Paul Fisher | | Baker's Dozen Gang Member (voice) |
| Aydrea Walden | | Baker's Dozen Gang Member (voice) |
