 | Sam Rockwell | | Wolf (voice) |
| Marc Maron | | Snake (voice) |
| Awkwafina | | Tarantula (voice) |
| Craig Robinson | | Shark (voice) |
| Anthony Ramos | | Piranha (voice) |
| Richard Ayoade | | Professor Marmalade (voice) |
| Zazie Beetz | | Diane Foxington aka The Crimson Paw (voice) |
| Alex Borstein | | Police Chief Misty Luggins (voice) |
| Lilly Singh | | Tiffany Fluffit (voice) |
| Barbara Goodson | | Old Lady (voice) |
| Dina Morrone | | Museum Announcer / Diane's A.I. Assistant (voice) |
| Michael Godere | | Delivery Driver / Museum Guest 1 (voice) |
| Kelly Cooney Cilella | | Prison Guard 1 / Gala Guest 1 (voice) |
| Kelly Cooney | | Prison Guard 1 / Gala Guest 1 (voice) |
| Walt Dohrn | | Scientist / Gala Guest 3 (voice) |
| David P. Smith | | Prison Guard 2 / Gala Guest 2 / Protestor (voice) |
| John Venzon | | Museum Guest 2 / Panicked Cop (voice) |
| John Venzon | | Museum Guest 2 / Panicked Cop (voice) |
| Jesse Averna | | Prison Guard 3 (voice) |
