 | Russell Crowe | | Capt. Jack Aubrey |
| Paul Bettany | | Dr. Stephen Maturin, Surgeon |
| James D'Arcy | | 1st Lt. Tom Pullings |
| Edward Woodall | | 2nd Lt. William Mowett |
| Chris Larkin | | Capt. Howard, Royal Marines |
| Max Pirkis | | Blakeney, Midshipman |
| Jack Randall | | Boyle, Midshipman |
| Max Benitz | | Calamy, Midshipman |
| Lee Ingleby | | Hollom, Midshipman |
| Richard Pates | | Williamson, Midshipman |
| Billy Boyd | | Barrett Bonden, Coxswain |
| Robert Pugh | | Mr. Allen, Master |
| Richard McCabe | | Mr. Higgins, Surgeon's Mate |
| Joseph Morgan | | William Warley, Cpt. of Mizzentop |
| Ian Mercer | | Mr. Hollar, Boatswain |
| Patrick Gallagher | | Awkward Davies, Able Seaman |
| David Threlfall | | Preserved Killick, Captain's Steward |
| Tony Dolan | | Mr. Lamb, Carpenter |
| Bryan Dick | | Joseph Nagle, Carpenter's Mate |
| George Innes | | Joe Plaice, Able Seaman |
| William Mannering | | Faster Doudle, Able Seaman |
| Alex Palmer | | Nehemiah Slade, Able Seaman |
| Mark Lewis Jones | | Mr. Hogg, Whaler |
| John DeSantis | | Padeen, Loblolly Boy |
| Ousmane Thiam | | Black Bill, Killick's Mate |
| Thierry Segall | | French Captain |
