 | Tom Cruise | | Capt. Pete 'Maverick' Mitchell |
| Jennifer Connelly | | Penny Benjamin |
| Miles Teller | | Lt. Bradley 'Rooster' Bradshaw |
| Val Kilmer | | Adm. Tom 'Iceman' Kazansky |
| Bashir Salahuddin | | Wo-1. Bernie 'Hondo' Coleman |
| Jon Hamm | | Adm. Beau 'Cyclone' Simpson |
| Charles Parnell | | Adm. Solomon 'Warlock' Bates |
| Monica Barbaro | | Lt. Natasha 'Phoenix' Trace |
| Jay Ellis | | Lt. Reuben 'Payback' Fitch |
| Lewis Pullman | | Lt. Robert 'Bob' Floyd |
| Danny Ramirez | | Lt. Mickey 'Fanboy' Garcia |
| Glen Powell | | Lt. Jake 'Hangman' Seresin |
| Jake Picking | | Lt. Brigham 'Harvard' Lennox |
| Manny Jacinto | | Lt. Billy 'Fritz' Avalone |
| Jack Schumacher | | Lt. Neil 'Omaha' Vikander |
| Raymond Lee | | Lt. Logan 'Yale' Lee |
| Chelsea Harris | | Admiral's Aide |
| Kara Wang | | Lt. Callie 'Halo' Bassett |
| Jean Louisa Kelly | | Sarah Kazansky |
| Greg Tarzan Davis | | Lt. Javy 'Coyote' Machado |
| Ed Harris | | Radm. Chester 'Hammer' Cain |
| Rachel Winfree | | Waitress |
| Bob Stephenson | | Senior Engineer |
| James Handy | | Bartender (Jimmy) |
| Lyliana Wray | | Amelia |
| Darnell Kirkwood | | Comms-Crew Techs |
| Austin Bowerman | | Comms-Crew Tech |
| Stephanie Andrea Barron | | Comms-Crew Tech |
| Alec Williams | | Cain's Aide |
| Peter Mark Kendall | | Meek Engineer |
| Ian Gary | | Jaded Engineer |
| Landon Gordon | | Kid in Truck Stop |
| Margatet Strabala | | Air Control Officer |
| Ryan Heilmann | | Air Control Officer |
| Shantel Limbo | | Staff Sergeant |
| Whylip Lee | | Fuel |
| Tristan Henry | | Surfaces |
| Jason Robert Boles | | Mini Boss |
| Brian Ferguson | | Fighter Pilot in Bar |
| Chido Nwokocha | | Mission Controller |
