| Jack Black | | Po |
| Awkwafina | | Zhen |
| Viola Davis | | The Chameleon |
| Dustin Hoffman | | Shifu |
| Bryan Cranston | | Li |
| James Hong | | Mr. Ping |
| Ian McShane | | Tai Lung |
| Ke Huy Quan | | Han |
| Ronny Chieng | | Fish |
| Lori Tan Chinn | | Granny Boar |
| Seth Rogen | | Mantis |
| Jimmy Donaldson | | Panda Pig |
| James Murray | | Boastful Komodo / Frightened Ram / Goose Jail Guard / Bunny Bartender |
| James Sie | | Bull Officer #2 / Ram Worker / Master Villain #1 |
| Cedric Yarbrough | | Bull Officer #1 / Ram Foreman / Questioned Boar |
| Vic Chao | | Bear Crime Boss / Last Ram / Tavern Patron #2 |
| Audrey Brooke | | Den Bunny #2 / Piglet #1 / Piglet #2 / Action Figure Pig Kid, Picture Bunny Kid / Restaurant Bunny #2 |
| Lincoln Nakamura | | Den Bunny #3 / Action Figure Panda Kid / Restaurant Bunny #3 |
| Cece Valentina | | Den Bunny #1 / Restaurant Bunny #1 |
| April Hong | | Pig Patron #2 |
| Suzanne Buirgy | | Autograph-Seeking Fan #1 |
| Logan Kim | | Autograph-Seeking Fan #2 |
| Reyn Doi | | Adoring Fan |
| Mick Wingert | | Old Bunny Patron |
| Peggy Etra | | Pig Patron #1 / Questioned Croc |
| Gedde Watanabe | | Badger Crime Boss |
| Karen Maruyama | | Wolf Crime Boss / Bunny Waiter / Citizen #1 / Questioned Sheep |
| Tom McGrath | | Croc Crime Boss |
| Phil LaMarr | | Disheveled Bunny / Pig Thief / Questioned Bull |
| Mike Mitchell | | Tavern Patron #3 / Citizen #4 |
| Colleen Smith | | Antelope Thief / Citizen #2 / Tavern Patron #1 / Master Villain #2 |
| Sarah Sarang Oh | | Questioned Antelope / Citizen #3 |
| Paul Pape | | Transforming Rhino |
| James Taku Leung | | Transforming Wolf |
| Steve Alterman | | Transforming Croc |
| Christopher Knights | | Annoyed Komodo |
| Harry Shum Jr. | | Fire-Breathing Croc |