 | Sean Young | | Dr. Stephanie Brody |
| Michael McKean | | Dr. Simon August |
| Gary Friedkin | | Dr. Milton Chamberlain |
| Kyle T. Heffner | | Dr. Charles Litto |
| Rick Overton | | Dr. Thurman Flicker |
| Crystal Bernard | | Julie |
| Ted McGinley | | Dr. Bucky DeVol |
| Saul Rubinek | | Floyd Kurtzman |
| Harry Dean Stanton | | Dr. Oliver Ludwig |
| Pamela Reed | | Nurse Norine Sprockett |
| Taylor Negron | | Dr. Phil Burns |
| Patrick Collins | | Dr. Walter Rist |
| Dabney Coleman | | Dr. Joseph Prang |
| Titos Vandis | | Sal Bonafetti |
| Michael Richards | | Malamud |
| Hector Elizondo | | Angelo / Angela Bonafetti |
| Haunani Minn | | The Nurses - Chang |
| Becky Gonzalez | | The Nurses - Perez |
| Lynne Marie Stewart | | The Nurses - Thatcher |
| Esther Sutherland | | The Nurses - Willa Mae |
| Ann Washington | | The Nurses - Annie |
| Hillary Horan | | The Nurses - Theresa |
| Coleen Maloney | | The Nurses - Jones |
| Claudia Crown | | The Nurses - Sanchez |
| Sonya Jennings | | The Nurses - Nina |
| Kelly Moran | | The Nurses - Skateboard Nurse |
| Patti Proctor | | The Candystripers - Valerie |
| Toni Hudson | | The Candystripers - Bunny |
| Kimberly McArthur | | The Candystripers - Jyll Omato |
| Julie Roth | | The Candystripers - Glenda |
| Arlene Eustis | | The Candystripers - Bobby |
| Deborah Lacey | | The Candystripers - Phone Striper |
| Ellaraino | | The Surgeons - Doctor Stevens |
| Arnold Margolin | | The Surgeons - Doctor Whitehat |
| Charlie Brill | | The Surgeons - Doctor Quick |
| Thomas Byrd | | The Surgeons - New Intern |
| Frank Pesce | | The Gangsters - Rocco |
| Tessa Richarde | | The Gangsters - Rocco's Wife |
| Nicholas Mele | | The Gangsters - Jerry |
| Jill Owens | | The Gangsters - Angelo's Wife |
