| Jim Henson | | Kermit the Frog / Rowlf / Dr. Teeth / Waldorf / Swedish Chef / Ernie / Granny / Horse & Carriage Rider / Link Hogthrob / The Newsman / Baby Kermit / Baby Rowlf (voice) |
| Frank Oz | | Miss Piggy / Fozzie / Animal / Bert / Cookie Monster / Ocean Breeze Soap Board Member / Sam the Eagle / Baby Piggy / Baby Fozzie / Baby Animal (voice) |
| Dave Goelz | | Gonzo / Chester the Rat / Bill the Frog / Zoot / Beauregard / Jim the Dog / Dr. Bunsen Honeydew / Baby Gonzo Honeydew / Penguin (voice) |
| Steve Whitmire | | Rizzo the Rat / Gill the Frog / Chicken / College Student in Audience / Dog (voice) |
| Richard Hunt | | Scooter / Statler / Janice / Beaker / Dog / Baby Scooter (voice) |
| Jerry Nelson | | Camilla / Lew Zealand / Floyd / Bear / Chicken / Crazy Harry / Dog / Dr. Julius Strangepork / Granny / Penguin / Pops (voice) |
| Juliana Donald | | Jenny |
| Lonny Price | | Ronnie Crawford |
| Louis Zorich | | Pete |
| Art Carney | | Bernard Crawford |
| James Coco | | Mr. Skeffington |
| Dabney Coleman | | Martin Price / Murray Plotsky |
| Gregory Hines | | Roller Skater |
| Linda Lavin | | Kermit's Doctor |
| Joan Rivers | | Perfume Saleswoman |
| Elliott Gould | | Cop in Pete's |
| Liza Minnelli | | Liza Minnelli |
| Brooke Shields | | Customer in Pete's |
| Frances Bergen | | Leonard Winesop's Receptionist |
| Ed Koch | | The Honorable Edward I. Koch |
| John Landis | | Leonard Winesop |
| Vincent Sardi Jr. | | Vincent Sardi Jr. |
| Kathryn Mullen | | Jill the Frog / Chicken (voice) |
| Karen Prell | | Yolanda the Rat / Frank the Dog (voice) |
| Brian Meehl | | Tatooey the Rat / Bear / Dog (voice) |
| Bruce Edward Hall | | Masterson the Rat / Beth Bear (voice) |
| James J. Kroupa | | Additional Muppet Performer |
| David Rudman | | Additional Muppet Performer |
| Melissa Whitmire | | Additional Muppet Performer |
| Michael Earl | | Additional Muppet performer |
| Glenngo King | | Additional Muppet Performer |
| Tim de Haas | | Additional Muppet Performer |
| Cheryl Bartholow | | Additional Muppet Performer |
| Martin P. Robinson | | Additional Muppet Performer / College Student in Audience / Bear |
| Steve Burnett | | College Student |
| Mary Lou Harris | | College Student |
| Gates McFadden | | Mr. Price's Secretary |
| Joanne Hamlin | | Woman in Price's Office |
| Hector Troy | | First Cop |
| Norman Bush | | Second Cop |