| Jim Henson | | Kermit the Frog / Rowlf / Dr. Teeth / Waldorf / Swedish Chef / Link Hogthrob / Doc Hopper's Men (voice) |
| Frank Oz | | Miss Piggy / Fozzie Bear / Animal / Sam the Eagle / Doc Hopper's Men / Marvin Suggs / Swedish Chef (assistant) / Motorcycle Guy (voice) |
| Jerry Nelson | | Floyd Pepper / Crazy Harry / Robin the Frog / Lew Zealand / Camilla / Blue Frackle (voice) |
| Richard Hunt | | Scooter / Statler / Janice / Sweetums / Beaker / Fozzie Bear (assistant) (voice) |
| Dave Goelz | | The Great Gonzo / Zoot / Dr. Bunsen Honeydew / Doglion / Iraqian in El Sleezo Cafe / Nigel / Pig (voice) |
| Charles Durning | | Doc Hopper |
| Austin Pendleton | | Max |
| Edgar Bergen | | Self / Charlie McCarthy |
| Milton Berle | | Mad Man Mooney |
| Mel Brooks | | Professor Max Krassman |
| James Coburn | | El Sleezo Cafe Owner |
| Dom DeLuise | | Bernie the Agent |
| Elliott Gould | | Beauty Contest Compere |
| Bob Hope | | Ice Cream Vendor |
| Madeline Kahn | | El Sleezo Patron |
| Carol Kane | | Myth |
| Cloris Leachman | | Lord's Secretary |
| Steve Martin | | Insolent Waiter |
| Richard Pryor | | Balloon Vendor |
| Telly Savalas | | El Sleezo Tough |
| Orson Welles | | Lew Lord |
| Paul Williams | | El Sleezo Pianist |
| Scott Walker | | Frog Killer |
| Lawrence Gabriel Jr. | | Sailor |
| Ira F. Grubman | | Bartender |
| H.B. Haggerty | | Lumberjack |
| Bruce Kirby | | Gate Guard |
| Tommy Madden | | One-Eyed Midget |
| James Frawley | | Waiter |
| Arnold Roberts | | Cowboy |
| Steve Whitmire | | Fletcher Bird / Scooter (assistant) (voice) |
| Kathryn Mullen | | Camilla (assistant) |
| Bob Payne | | Muppet Performer |
| Eren Ozker | | Muppet Performer |
| Caroly Wilcox | | Muppet Performer |
| Olga Felgemacher | | Muppet Performer |
| Bruce Schwartz | | Muppet Performer |
| Michael Earl | | Animal (assistant) / Beaker (assistant) / Big Bird (assistant) / Dr. Teeth (assistant) / Fozzie Bear (assistant) / Janice (assistant) / Scooter (assistant) |
| Buz Suraci | | Muppet Performer |
| Tony Basilicato | | Muppet Performer |