| Ryan Reynolds | | Turbo (voice) |
| Paul Giamatti | | Chet (voice) |
| Michael Peña | | Tito (voice) |
| Samuel L. Jackson | | Whiplash (voice) |
| Luis Guzmán | | Angelo (voice) |
| Bill Hader | | Guy Gagné (voice) |
| Snoop Dogg | | Smoove Move (voice) |
| Maya Rudolph | | Burn (voice) |
| Ben Schwartz | | Skidmark (voice) |
| Richard Jenkins | | Bobby (voice) |
| Ken Jeong | | Kim Ly (voice) |
| Michelle Rodriguez | | Paz (voice) |
| Mario Andretti | | Dos Bros Customer / Race Official (voice) |
| Mike Bell | | White Shadow (voice) |
| Aidan Andrews | | Bike Boy (voice) |
| Aaron Berger | | Danny (voice) |
| Jen Cohn | | Network Reporter (voice) |
| Ryan Crego | | VIP (voice) |
| Rich Dietl | | Tomato Slicer / Reporter (voice) |
| Paul Dooley | | The Foreman (voice) |
| Derek Drymon | | Worker Snail #2 / FAST Network Trackside Reporter (voice) |
| Susan Fitzer | | Sally / American Anchor (voice) |
| Dario Franchitti | | Scottish Anchor / Male Tourist (voice) |
| Brian Hopkins | | Lookout Snail (voice) |
| Joseph Izzo | | FAST Network Announcer / Security Guard #1 (voice) |
| Gordon James | | Security Guard #2 (voice) |
| Andrea Montana Knoll | | Worker Snail #7 / Female Tourist (voice) |
| Chris Miller | | Tour Bus Driver (voice) |
| Latifa Ouaou | | Worker Snail #3 (voice) |
| Paul Page | | Announcer #1 (voice) |
| Chris Parnell | | Announcer #2 (voice) |
| Will Power | | Australian Anchor (voice) |
| Lashana Rodriguez | | Radio DJ / Hot Oven (voice) |
| James Ryan | | Phil / Plant Worker / Takao Noguchi (voice) |
| Lloyd Sherr | | Spanish DJ (voice) |
| Kurtwood Smith | | Indy CEO (voice) |
| David Soren | | Worker Snail #1 / Can't Tuck Snail / Gagne's Crew Chief / Indy Network Executive / Newspaper Boy / Autotune Kid (voice) |
| Paul Soren | | Worker Snail #5 (voice) |
| Lisa Stewart | | Worker Snail #4 / Indy Marketing Executive (voice) |
| Mark Walton | | Official (voice) |