| Michael B. Jordan | | Adonis Creed |
| Tessa Thompson | | Bianca Creed |
| Jonathan Majors | | Damian Anderson |
| Wood Harris | | Tony 'Little Duke' Burton |
| Phylicia Rashad | | Mary-Anne Creed |
| Mila Davis-Kent | | Amara Creed |
| Jose Benavidez | | Felix Chavez |
| Selenis Leyva | | Laura Chavez |
| Florian Munteanu | | Viktor Drago |
| Thaddeus J. Mixson | | Adonis Creed (15) |
| Spence Moore II | | Damian Anderson (18) |
| Tony Bellew | | 'Pretty' Ricky Conlan |
| Patrice Harris | | Boog |
| Ann Najjar | | Ann |
| Jacob 'Stitch' Duran | | Stitch |
| Terence Crawford | | Lorenzo 'Nightmare' Jones |
| Bobby Hernandez | | Conlan's Trainer |
| Yahya McClain | | Damian's Trainer |
| Lamont Lankford | | Damian's Cutman |
| Corey Calliet | | Additional Creed Cornerman |
| Kenny Bayless | | Referee Kenny Bayless |
| Todd Grisham | | DAZN Broadcaster Todd Grisham |
| Jessica McCaskill | | DAZN Broadcaster Jessica 'Caskilla' McCaskill |
| Maya Page | | Ring Girl |
| Jimmy Lennon Jr. | | Ring Announcer Jimmy Lennon Jr. |
| Russell Mora | | Referee Russell Mora |
| Al Bernstein | | Showtime Broadcaster Al Bernstein |
| Mauro Ranallo | | Showtime Broadcaster Mauro Ranallo |
| Brianna Valeria Gonzalez Vazquez | | Ring Girl |
| Shayra Medal | | Ring Girl |
| Kimberly Davis | | Fight Interpreter |
| David Diamante | | Ring Announcer David Diamante |
| Tony Weeks | | Referee Tony Weeks |
| Christopher Lee Mannix | | DAZN Broadcaster Christopher Mannix |
| Chris Mannix | | DAZN Broadcaster Christopher Mannix |
| Andreia Gibau | | Ring Girl |
| Soraya Yd | | Ring Girl |
| Stephen A. Smith | | Stephen A. Smith |
| Barry Pepper | | Voice Of Showtime® All Access (voice) |
| Jessica Holmes | | KTLA Co-Anchor Jessica Holmes |
| Canelo Álvarez | | Canelo Alvarez |