 | Hugh Jackman | | Roddy (voice) |
| Kate Winslet | | Rita (voice) |
| Ian McKellen | | The Toad (voice) |
| Jean Reno | | Le Frog (voice) |
| Bill Nighy | | Whitey (voice) |
| Andy Serkis | | Spike (voice) |
| Shane Richie | | Sid (voice) |
| Kathy Burke | | Rita's Mum (voice) |
| David Suchet | | Rita's Dad (voice) |
| Miriam Margolyes | | Rita's Grandma (voice) |
| Rachel Rawlinson | | Tabitha (voice) |
| Susan Duerden | | Mother (voice) |
| Miles Richardson | | Father (voice) |
| John Motson | | Football Commentator (voice) |
| Douglas Weston | | Newspaper Seller (voice) |
| Roger Blake | | Policeman / Balloon Seller (voice) |
| Christopher Fairbank | | Thimblenose Ted / Cockroach / Passerby (voice) |
| Paul Shardlow | | Pegleg (voice) |
| Conrad Vernon | | Take Out (voice) |
| Jonathan Kydd | | Barnacle (voice) |
| Newell Alexander | | Tex (voice) |
| Susan Fitzer | | Edna (voice) |
| Joshua Silk | | Fergus (voice) |
| Meredith Wells | | Rita's Little Sister (voice) |
| Ashleigh-Louis Elliot | | Rita's Sister #2 (voice) |
| Ashleigh Ludwig | | Rita's Sister #3 (voice) |
| Christopher Knights | | Fat Barry / Market Trader (voice) |
| Emma Tate | | Fly-Lady / Passerby #2 (voice) |
| Tom McGrath | | Action Figure / Artist (voice) |
| Sam Fell | | Liam / Prophet / Ladykiller / Fanseller (voice) |
| David Bowers | | Goldfish / Fly / Shocky / Henchfrog #1 / Tadpole (voice) |
