| Michelle Pfeiffer | | Ingrid (segment "Resolution Tour") |
| Zac Efron | | Paul (segment "Resolution Tour") |
| Charlotte Marshall-Fricker | | Caring Teenage Girl (segment "Resolution Tour") |
| Fiona Choi | | Balinese Woman (segment "Resolution Tour") |
| Mary Marguerite Keane | | Pet Adoption Clerk (segment "Resolution Tour") |
| Michael Mandell | | Murray (segment "Resolution Tour") |
| Patrick Reale | | Times Square Cop (segment "Resolution Tour") |
| Robert De Niro | | Stan Harris (segment "Hospital Story") |
| Halle Berry | | Nurse Aimee (segment "Hospital Story") |
| Cary Elwes | | Stan's Doctor (segment "Hospital Story") |
| Alyssa Milano | | Nurse Mindy (segment "Hospital Story") |
| Common | | Soldier (segment "Hospital Story") |
| Barbara Marshall | | Head Nurse Helen (segment "Hospital Story") |
| Jessica Biel | | Tess Byrne (segment "Maternity Ward") |
| Seth Meyers | | Griffin Byrne (segment "Maternity Ward") |
| Sarah Paulson | | Grace Schwab (segment "Maternity Ward") |
| Til Schweiger | | James Schwab (segment "Maternity Ward") |
| Carla Gugino | | Spiritual Dr. Morriset (segment "Maternity Ward") |
| Amber Bela Muse | | Nurse Risa (segment "Maternity Ward") |
| Peter Allen Vogt | | Male Nurse (segment "Maternity Ward") |
| Katherine Heigl | | Laura (segment "Jensen & Laura's Story") |
| Jon Bon Jovi | | Jensen (segment "Jensen & Laura's Story") |
| Sofía Vergara | | Ava (segment "Jensen & Laura's Story") |
| Russell Peters | | Chef Sunil (segment "Jensen & Laura's Story") |
| Ashton Kutcher | | Randy (segment "Elevator") |
| Sarah Jessica Parker | | Kim (segment "Mother & Daughter") |
| Abigail Breslin | | Hailey (segment "Mother & Daughter") |
| Jake T. Austin | | Seth (segment "Mother & Daughter") |
| Nat Wolff | | Walter (segment "Mother & Daughter") |
| Katherine McNamara | | Lily Bowman |
| Josh Duhamel | | Sam |
| Cherry Jones | | Mrs. Rose Ahern |
| Hilary Swank | | Claire Morgan |
| Ludacris | | Brendan |
| Kathleen Marshall | | Stage Manager Charlotte |
| Ross Ryman | | Pedicab Driver (segment "Maternity Ward") |
| Kal Parekh | | Male Obstetrician (segment "Maternity Ward") |
| Serena Poon | | Chef Ming (segment "Jensen & Laura's Story") |
| Sarge | | Monty (segment "Jensen & Laura's Story") |
| Lea Michele | | Elise (segment "Elevator") |
| Jim Belushi | | Building Super (segment "Elevator") |
| Lillian Lifflander | | Mrs. Lifflander (segment "Elevator") |
| Mara Davi | | Mika (segment "Mother & Daughter") |
| Jaclyn Miller | | Choreographer (segment "Mother & Daughter") |
| Cassidy Reiff | | Piper (segment "Mother & Daughter") |
| Kendra Jain | | Kelly (segment "Mother & Daughter") |