| Irene Bedard | | Pocahontas (voice) |
| Jim Cummings | | King James (voice) |
| Donal Gibson | | John Smith (voice) |
| Finola Hughes | | Queen Anne (voice) |
| Linda Hunt | | Grandmother Willow (voice) |
| Russell Means | | Powhatan (voice) |
| David Ogden Stiers | | Ratcliffe (voice) |
| Jean Stapleton | | Mrs. Jenkins (voice) |
| Billy Zane | | John Rolfe (voice) |
| Jeff Bennett | | Additional voices (voice) |
| Brad Garrett | | Uttamatomakkin (voice) |
| Rob Paulsen | | Additional voices (voice) |
| Gregg Rainwater | | Additional voices (voice) |
| William Morgan Sheppard | | Additional voices (voice) |
| Kath Soucie | | Additional voices (voice) |
| Russell Werkman | | Additional voices (voice) |
| April Winchell | | Additional voices (voice) |
| Bob Bergen | | Additional voices (voice) |
| Mark S. Brien | | Additional voices (voice) |
| Rodger Bumpass | | Additional voices (voice) |
| Jennifer Darling | | Additional voices (voice) |
| Debi Derryberry | | Additional voices (voice) |
| Paul Eiding | | Additional voices (voice) |
| Bill Farmer | | Additional voices (voice) |
| Jonathan Joss | | Additional voices (voice) |
| Georgina Lightning | | Additional voices (voice) |
| Mickie McGowan | | Additional voices (voice) |
| Phil Proctor | | Additional voices (voice) |
| Andrew Roa | | Additional voices (voice) |
| Marjorie Tanin | | Additional voices (voice) |
| Darrell James | | Rotoscope Actor |
| Judy Kuhn | | Pocahont |
| Tim Weske | | John Smith |