 | Noomi Rapace | | Elizabeth Shaw |
| Michael Fassbender | | David |
| Charlize Theron | | Meredith Vickers |
| Idris Elba | | Janek |
| Guy Pearce | | Peter Weyland |
| Logan Marshall-Green | | Charlie Holloway |
| Sean Harris | | Fifield |
| Rafe Spall | | Millburn |
| Emun Elliott | | Chance |
| Benedict Wong | | Ravel |
| Kate Dickie | | Ford |
| Branwell Donaghey | | Mercenary 1 |
| Vladimir 'Furdo' Furdik | | Mercenary 2 |
| C.C. Smiff | | Mercenary 3 |
| Shane Steyn | | Mercenary 4 |
| Ian Whyte | | Last Engineer |
| John Lebar | | Ghost Engineer |
| Daniel James | | Sacrifice Engineer |
| Patrick Wilson | | Shaw's Father |
| Lucy Hutchinson | | Young Shaw |
| Giannina Facio | | Shaw's Mother |
| Anil Biltoo | | Linguist Teacher |
| Louisa Staples | | Greeting Message Violinist |
| James Embree | | Mechanic 1 |
| Florian Robin | | Mechanic 2 |
| Matthew Burgess | | Mechanic 3 |
| Eugene O'Hare | | Mechanic 4 |
| Richard Thomson | | Archaeological Assistant |
| Philip McGinley | | Archaeological Assistant |
| Jenny Rainsford | | Archaeological Assistant |
| Rhona Croker | | Archaeological Assistant |
| Wambui Wa-Ngatho | | Automated Voice (Swahili) (voice) |
| Wannaporn Rienjang | | Automated Voice (Thai) (voice) |
| Zed Sevcikova | | Automated Voice (Czech) (voice) |
| Sonam Dugdak | | Automated Voice (Tibetan) (voice) |
| Reynir Thor Eggertsson | | Automated Voice (Icelandic) (voice) |
| Shin-Ichiro Okajima | | Automated Voice (Japanese) (voice) |
| Charalambos Dendrinos | | Automated Voice (Greek) (voice) |
| Berhane Woldegabriel | | Automated Voice (Amharic) (voice) |
| Annie Penn | | Ship Computer Voice (voice) |
