| Jerry Seinfeld | | Barry B. Benson (voice) |
| Renée Zellweger | | Vanessa Bloome (voice) |
| Matthew Broderick | | Adam Flayman (voice) |
| Patrick Warburton | | Ken (voice) |
| John Goodman | | Layton T. Montgomery (voice) |
| Chris Rock | | Mooseblood (voice) |
| Kathy Bates | | Janet Benson (voice) |
| Barry Levinson | | Martin Benson (voice) |
| Larry King | | Bee Larry King (voice) |
| Ray Liotta | | Ray Liotta (voice) |
| Sting | | Sting (voice) |
| Oprah Winfrey | | Judge Bumbleton (voice) |
| Larry Miller | | Buzzwell (voice) |
| Megan Mullally | | Trudy (voice) |
| Rip Torn | | Lou Lo Duca (voice) |
| Michael Richards | | Bud Ditchwater (voice) |
| Mario Joyner | | Jackson (voice) |
| Jim Cummings | | Title Narrator / Graduation Announcer (voice) |
| Tom Papa | | Splitz / Klauss Vanderhayden (voice) |
| Andy Robin | | Jock #2 (voice) |
| David Moses Pimentel | | Hector (voice) |
| Chuck Martin | | Andy (voice) |
| Conrad Vernon | | Freddy (voice) |
| David Herman | | Buzz / Bob Bumble / Pilot (voice) |
| Carol Leifer | | Press Person #1 (voice) |
| Jeff Altman | | Uncle Carl (voice) |
| Brian Hopkins | | Sandy Shrimpkin / TSA Agent (voice) |
| Tress MacNeille | | Jeanette Chung / Mother / Cow (voice) |
| Nathan D. Morrissey | | Boy Crying / Timmy (voice) |
| Olivia Mattingly | | Little Girl (voice) |
| Simon J. Smith | | Truck Driver / Chet (voice) |
| Geoff Witcher | | Press Person #2 / Jock #1 (voice) |
| John DiMaggio | | Janitor / Bailiff (voice) |
| Barry Marder | | Waterbug (voice) |
| Sean Bishop | | Ladybug (voice) |