| Toni Collette | | Mary Daisy Dinkle (voice) |
| Philip Seymour Hoffman | | Max Jerry Horovitz (voice) |
| Eric Bana | | Damien Popodopolous (voice) |
| Daniel Marks | | Alleyway Bully Three (voice) |
| Christopher Massey | | 911 Operator / Ambulance Voice / Derisive Observer (voice) |
| Oliver Marks | | Alleyway Bully One (voice) |
| Daisy Kocher | | Alleyway Bully Two / Bird Injury Girl / Bus Stop Girl / Katherine Ramsay (voice) |
| Hamish Hughes | | Animals (Miscellaneous) / Mad Jury Member / Opera Singer Two (voice) |
| Dan Doherty | | BMX Bandit (voice) |
| Julie Forsyth | | Bus Stop Mother / Kissing Woman (voice) |
| Mandy Mao | | Cher the Chihuahua / Sonny the Chihuahua (voice) |
| Patrick McCabe | | Datsun Sunny Driver (voice) |
| Adam Elliot | | Dr. Bernard Hazelhof / Garbo Two / Grandpappy Ralph / Ivan Ruby Bevan / Mr. Ravioli / Postmaster / Runover Kitten / Worm (voice) |
| Mr. Peck | | Ethel the Rooster (voice) |
| Michael James Allen | | Ferrari Driver (voice) |
| Bill Murphy | | Frankston Icebreaker One (voice) |
| Shaun Patten | | Frankston Icebreaker Two (voice) |
| Bernie Clifford | | Garbo One (voice) |
| Milly | | Hal the Cat (voice) |
| John Flaus | | Harvey Krumpet / Ken / Len Hislop (voice) |
| Henry Karjalainen | | Henry the Fish (voice) |
| Ian 'Molly' Meldrum | | Homeless Man (voice) |
| Kevin | | Kevin the Pug (voice) |
| Chris Wallace | | Lottery Caller / New Yorker Two (voice) |
| Marlee Bevan | | Mary's Baby (voice) |
| Indy | | Mr. Biscuit the Parrot (voice) |
| Melanie Coombs | | Mrs. Pendergast (voice) |
| Barry Humphries | | Narrator (voice) |
| Carolyn Shakespeare-Allen | | New York Callgirl / New Yorker One (voice) |
| Alf Klimek | | New Yorker Three (voice) |
| Antoinette Halloran | | Opera Singer (voice) |
| Leanne Smith | | Overeaters Anonymous Tutor / Post Office Customer / Zelda Glutnik (voice) |
| Stephen Carroll | | Thespian One (voice) |
| Renée Geyer | | Vera Lorraine Dinkle (voice) |
| Athanasios Kourtidis | | Wedding Reception Guest (voice) |
| Yorgos Kourtidis | | Wedding Reception Guest (voice) |
| Bethany Whitmore | | Young Mary Daisy Dinkle (voice) |