| Miles Teller | | Reed Richards |
| Michael B. Jordan | | Johnny Storm |
| Kate Mara | | Sue Storm |
| Jamie Bell | | Ben Grimm / The Thing |
| Toby Kebbell | | Victor Von Doom / Dr. Doom |
| Reg E. Cathey | | Dr. Franklin Storm |
| Tim Blake Nelson | | Dr. Allen |
| Joshua Montes | | Quarterback Speech School Kid |
| Dan Castellaneta | | Mr. Kenny |
| Owen Judge | | Young Reed |
| Kylen Davis | | Teasing School Kid |
| Evan Hannemann | | Young Ben |
| Wayne Pére | | Science Fair Judge (as Wayne Pere) |
| Chet Hanks | | Jimmy Grimm |
| Mary-Pat Green | | Mrs. Grimm |
| Tim Heidecker | | Mr. Richards |
| Mary Rachel Quinn | | Mrs. Richards |
| Rhonda Johnson Dents | | Science Fair Judge |
| Barney Lanning | | Science Fair Plane Kid |
| Dennis Thomas IV | | Baxter Security Guard |
| Abhi Trivedi | | Baxter Employee |
| Benjamin Papac | | Baxter Student |
| Jim Gleason | | Board Member |
| Gabe Begneaud | | Trash Talk Car Driver |
| Anna R. Parsons | | Girl Classmate |
| Brian Stapf | | Reed's Guard (Area 57) |
| Ben VanderMey | | Soldier (Area 57) |
| Elvin Presley | | Drag Race Official |
| Brittney Alger | | Street Race Girl |
| J.T. Rowland | | Monkey Test Lab Technician |
| Gretchen Koerner | | Reed's Scientist (Area 57) |
| Hunter Burke | | Reed's Scientist (Area 57) |
| Han Soto | | Reed's Doctor (Area 57) |
| Michael 'Mick' Harrity | | Military Interrogator (Area 57) |
| Melissa McCurley | | Sue's Doctor (Area 57) |
| Jane Rumbaua | | Johnny's Doctor (Area 57) |
| Anthony Reynolds | | Airplane Military Official (Area 57) |
| Spence Maughon | | Johnny's Technician (Area 57) |
| Lance E. Nichols | | DC Senior Official (Area 57) |
| Deneen Tyler | | DC Military Official (Area 57) |